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NYU Dataset
Intra-axonal Space Segmentation from 3D Scanning Electron Microscopy (SEM) of the Mouse Brain Genu of Corpus Callosum
- Authors
- Hong-Hsi LeeDmitry S. NovikovEls Fieremans
- Description
This dataset includes 3D scanning electron microscopy (SEM) images of a female mouse corpus callosum and MATLAB code for random walker (RaW) segmentations of myelinated axons. The code additionally characterizes inner axonal diameters and fiber orientation dispersion within segments of the intra-axonal spaces and myelin sheaths. In the study, a female 8-week-old C57BL/6 mouse was perfused trans-cardiacally...
- Subject
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AnatomyNeuroscience
- Access Rights
- Free to All
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NYU Dataset
High-density neural recordings of macaque monkeys performing a direction discrimination task
- Authors
- Roozbeh KianiChristopher J. CuevaJohn B. Reppas
- Description
The investigators collected simultaneous recordings using multi-channel electrode arrays attached to the prearcuate gyrus of macaque monkeys who performed a direction discrimination task with fixed stimulus duration. In the study, 96-channel multielectrode arrays were used to record from neural populations in area 8Ar of the prearcuate gyrus of three macaque monkeys, while they performed a direction...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
Evaluation of Metronomic Chemotherapy Response Using Diffusion and Dynamic Contrast-enhanced MRI
- Alternate Title(s)
- Evaluation of Metronomic Chemotherapy Response Using dMRI and DCE MRI
- Authors
- Mehran BaboliKerryanne V. WintersMelanie FreedJin Zhang1 more author(s)...
- Description
The dataset contains data collected from twelve Balb/c mice with metastatic breast cancer (4T1 mammary tumors). Six mice were in the control group and six mice were treated with 5-Fluorouracil (5FU) for metronomic chemotherapy for two weeks. Diffusion MRI (dMRI) and Dynamic Contrast-enhanced MRI (DCE-MRI) images were collected at baseline and post-treatment. Immunohistochemically (IHC) stains and measurements...
- Subject
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Cancer
- Access Rights
- Free to All
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NYU Dataset
Recordings of theta rhythm perturbation by focal cooling of the septal pacemaker in awake rats
- Authors
- Peter C. PetersenGyorgy Buzsaki
- Description
Electrophysiological recordings were obtained from male rats who were subjected to localized cooling of their medial septum (MS) prior to completing behavioral tasks. The MS is critical in theta generation. Therefore, temperature manipulation of the MS was used to test these models. Approximately 40 control trials were completed, followed by exposure to dry ice to reduce MS temperature for 20 to 60...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
3D-printable model and electrophysiological recordings for a headgear system for freely-moving rodents
- Authors
- Mihaly VoroslakosPeter C. PetersenBalázs VöröslakosGyorgy Buzsaki
- Description
The Buzsáki Lab has shared designs for a 3D-printed metal microdrive and head cap system for freely-moving rodents and sample electrophysiological recordings. The modular design allows for recovery and reuse of silicon probes in multiple experiments with mice and Long-Evans rats. The .step files for the metal microdrive are optimized for stainless steel 316L in 20 micrometer resolution and aluminum...
- Subject
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Neuroscience
- Access Rights
- Free to All
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Modeling Bayesian inference with incomplete knowledge in monkeys presented with a direction discrimination task with post-decision wagering
- Authors
- Koosha KhalvatiRoozbeh KianiRajesh P. N. Rao
- Description
The investigators collected behavioral data from two macaque monkeys (M1 and M2) who were presented with a direction discrimination task with post-decision wagering. These monkeys received prior training to report the net direction of motion of a set of randomly moving dots. In each trial, the subject fixed their gaze on an initial fixation point, then red dots would appear on the periphery of the...
- Subject
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Neuroscience
- Access Rights
- Free to All
- Local Expert
- Roozbeh Kiani
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NYU Dataset
Switch-like and persistent memory formation in individual Drosophila larvae
- Authors
- Amanda LesarJavan TahirJason WolkMarc Gershow
- Description
Using a Y-shaped maze, several experiments were developed to assess conditions of associative learning among fruit fly larvae. Prior to the start of the experiments, some fruit fly larvae were fed a diet of all-trans-retinal (ATR), which is a co-factor for csChrimson activation (eliciting escape behavior in flies which perceive red light). A subgroup of larvae who were fed ATR also received cycloheximide...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
Behavioral and Electrophysiology Data Indicates Wind Direction is Decoded by Central Neurons in Drosophila
- Authors
- Marie P. SuverAndrew M. M. MathesonSinekdha SarkarMatthew Damiata2 more author(s)...
- Description
Wind is a major navigational cue for insects and this study examined how wind direction is decoded by central neurons in the insect brain. They determined that flies combine signals from both antennae to orient to wind during olfactory search behavior. In Drosophila, movements of the antennae are detected by mechanosensory neurons, known as Johnston’s Organ (JO) neurons. The JO neurons project from...
- Subject
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Neuroscience
- Access Rights
- Free to All
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NYU Dataset
Studying Zika Virus Evolution In Vivo Using Insect-to-Mouse Transmission Model
- Authors
- Katherine E. E. JohnsonMaria G. NovalMargarita V. RangelElfie De Jesus5 more author(s)...
- Description
Arboviruses are caused by a group of viruses spread to people (host) by the bite of infected insects (vector). It is within these hosts that arboviruses replicate and undergo genomic evolution. However, how arboviruses evolve, are transmitted, or cause disease in nature remain unclear. Therefore, this study established a Zika virus (ZIKV) vector-borne transmission system in immunocompromised mice to...
- Subject
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GenomicsInfectious Disease
- Access Rights
- Free to All
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NYU Dataset
Electrophysiology and Imaging Data Identified Central Complex Neurons that Encode Airflow Direction in Drosophila
- Authors
- Timothy A. CurrierAndrew M. M. MathesonKatherine I. Nagel
- Description
This data was collected to identify the brain regions and circuit organizations that support navigation. In insects, the central complex (CX) is thought to control many aspects of navigation. The CX is a highly organized neuropil, which consists of the protocerebral bridge, the ellipsoid body, the fan-shaped body, and the paired noduli. This study contains electrophysiology, imaging, and behavioral...
- Subject
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Neuroscience
- Access Rights
- Free to All